Objective To explore the potential different association between genes polymorphisms and chronic obstructive pulmonary disease(COPD)phenotype in different geographic regions. Methods The population stratification meta-analysis and population structure analysis based on two COPD-related gene polymorphisms TNF-α-308G/A and EPHX1 His139/ Arg were performed. Results The results showed that EPHX1 His139/Arg is not associated with COPD whereas TNF-α-308G/A is obviously associated with COPD in Asia population. Conclusions The results demonstrate the importance of ethnicity and geographic regions in identifying specific COPD susceptibility genes. Key words: Chronic obstructive pulmonary disease; Population structure; Meta analysis

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