A population structure analysis using two chronic obstructive pulmonary disease related gene polymorphisms

Abstract

Objective To explore the potential different association between genes polymorphisms and chronic obstructive pulmonary disease(COPD)phenotype in different geographic regions. Methods The population stratification meta-analysis and population structure analysis based on two COPD-related gene polymorphisms TNF-α-308G/A and EPHX1 His139/ Arg were performed. Results The results showed that EPHX1 His139/Arg is not associated with COPD whereas TNF-α-308G/A is obviously associated with COPD in Asia population. Conclusions The results demonstrate the importance of ethnicity and geographic regions in identifying specific COPD susceptibility genes. Key words: Chronic obstructive pulmonary disease; Population structure; Meta analysis