Abstract
A straightforward route to trifluoromethyl analogs of piperidines is described. These syntheses involve a Barbier-type allylation reaction of trifluoroacetaldimines, followed by N-allylation (one-pot), and ring-closing metathesis. An efficient asymmetric version is also reported (>98 % de). Functionalized heterobicyclic compounds can also be obtained by a Pauson–Khand reaction. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
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