Abstract
The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT-MPI) that can be used for preclinical use for imaging small rodents (mice) injected with SPIONs not only in laboratories, but also at emergency sites far from laboratories. In particular, we applied a frequency mixing magnetic detection method to the PoCT-MPI, and proposed a hybrid field free line generator to reduce the power consumption, size and weight of the system. The PoCT-MPI is 20 times 33 times 45,{hbox{cm}}^3 in size and weighs less than 100 kg. It can image a three-dimensional distribution of SPIONs injected into a biosample with less than 120 Wh of power consumption. Its detection limit is 0.13,upmu {hbox{L}}, 10 mg/mL, 1.3,upmu {hbox{g}} (Fe).
Highlights
The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers
SPIONs, in addition, can be applied in biomedical diagnostics and therapeutics, because they can be conjugated with various biomolecules which can bind on the surface of the target diseased cells or organs
After the sample is loaded into the PoCT-MPI, the FMMD sensor and FFL generator are activated
Summary
The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We applied a frequency mixing magnetic detection method to the PoCT-MPI, and proposed a hybrid field free line generator to reduce the power consumption, size and weight of the system. Goodwill et al proposed the Projection MPI introducing x-space[7] They successfully implemented 3D MPI systems using two circular magnets and four Direct Current (DC) coil p airs[8]. These coils are used to electronically shift the FFP generated by NdFeB permanent magnets generating gradient fields of 7 × 3.5 × 3.5 T/m It can scans sophisticated samples of 45 × 120 mm[2] size by spatial resolution of 2 mm consuming 30 KW of power for an operation. As the demands for remote medical diagnosis technologies are increasing due to social needs such as aging and medical support in underdeveloped areas[14,15,16], it is necessary to reduce the power consumption, size and weight of the MPI system while preserving its sensitivity for the PoCT preclinical MPI application
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