Abstract
AbstractIn order to improve the solubility and the long‐cycle performance of hydrophobic drug sorafenib (SOR), and to obtain an ideal smart drug delivery system for the effective treatment of liver cancer, S‐SMIP, a pH/GSH double‐sensitive sorafenib stealth imprinting material, was successfully prepared by UV‐initiated surface imprinted polymerization on the basis of polyethylene glycol 2000 (PEG2000) acted as “gate keeper” modified magnetic substrate. The results showed that S‐SMIP had a good adsorption capacity of 260.0 mg g−1 and an excellent selectivity factor α 2.33. S‐SMIP's kinetic adsorption data accorded well with the pseudo‐second‐order model and its mechanism was controlled mainly by chemical adsorption. The drug release experiments in vitro indicated S‐SMIP could not only greatly improve the solubility of SOR, but also had the pH/GSH dual‐sensitive response performance. Compared with the non‐stealth imprinted material SMIP, S‐SMIP still had a better long‐cycle effect on the release of SOR, increasing to160 h from 130 h. So, the target material S‐SMIP could greatly prolong the half‐life of SOR, which provided a good idea for the development of a smart drug delivery system.
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