Abstract
ObjectiveLaboratory analysis results may provide an opportunity to predict the activity process of recurrent aphthous stomatitis. The goal of this study was to investigate whether there is a correlation between C-reactive protein to albumin ratio (CAR) and oral ulcer activity in patients with recurrent aphthous stomatitis.Materials and methodsWe included 72 patients (39 with active and 33 with inactive lesion) with recurrent aphthous stomatitis and 60 healthy controls. We compared blood test parameters including CAR, white blood cell count (WBC) and neutrophil to lymphocyte ratio (NLR) among the groups. Additionally, we investigated the most significant parameter for the activity of oral ulcers.ResultsNLR was significantly higher both in the active (p<0.001) and inactive lesion groups (p<0.001), compared to the control group but did not significantly differ between active and inactive lesion groups (p=0.17). A significant difference in median CAR (p<0.001) and WBC (p<0.001) was evident among the three groups. Median WBC was significantly higher in the active lesion group compared to the control group (p<0.001) but did not significantly differ between active and inactive lesion groups (p=0.095). Median CAR was significantly higher in the active lesion group, compared both to the inactive lesion group (p=0.002) and the control group (p<0.001). Median CAR was also significantly higher in the inactive lesion group compared to the control group (p<0.001). Median hemoglobin, platelet to lymphocyte ratio and mean platelet volume did not significantly differ among three groups (p=0.16, p=0.85, p=0.19, respectively).ConclusionCAR could be used as a predictive parameter for inflammation and activity of oral ulcers in patients with recurrent aphthous stomatitis.
Highlights
Recurrent aphthous stomatitis (RAS) is a disease characterized by painful, recurrent, round or oval-shaped ulcers of the oral mucosa
Albumin level is known to be decreased in acute inflammation, as well as in the ongoing chronic process of inflammation and under poor nutritional conditions [10, 11]
Several prior studies suggested that albumin levels were closely related to inflammation severity, disease prognosis, and mortality [9,10,11]
Summary
Recurrent aphthous stomatitis (RAS) is a disease characterized by painful, recurrent, round or oval-shaped ulcers of the oral mucosa. The etiopathogenesis of RAS has not been clearly understood but infection-related, genetic, familial, hormonal, allergic, psychological, traumatic and/or nutritional factors and inflammatory response were suspected [2]. C-reactive protein (CRP) is a positive acute-phase reactant synthesized by the liver and used in the diagnosis of infections and/or evaluation of the effectivity of treatment [6]. Physicians usually use it in the follow-up of an infection or inflammation as a prognostic parameter for the disease because of its short half-life and easy detection feature [6,7,8]. In patients with inflammation and infection, CRP levels usually increase, and albumin levels are expected to decrease [12, 13]
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