Abstract
Background: We validated a new noninvasive tool (B4C) to assess intracranial pressure waveform (ICPW) morphology in a set of neurocritical patients, correlating the data with ICPW obtained from invasive catheter monitoring. Materials and Methods: Patients undergoing invasive intracranial pressure (ICP) monitoring were consecutively evaluated using the B4C sensor. Ultrasound-guided manual internal jugular vein (IJV) compression was performed to elevate ICP from the baseline. ICP values, amplitudes, and time intervals (P2/P1 ratio and time-to-peak [TTP]) between the ICP and B4C waveform peaks were analyzed. Results: Among 41 patients, the main causes for ICP monitoring included traumatic brain injury, subarachnoid hemorrhage, and stroke. Bland–Altman’s plot indicated agreement between the ICPW parameters obtained using both techniques. The strongest Pearson’s correlation for P2/P1 and TTP was observed among patients with no cranial damage (r = 0.72 and 0.85, respectively) to the detriment of those who have undergone craniotomies or craniectomies. P2/P1 values of 1 were equivalent between the two techniques (area under the receiver operator curve [AUROC], 0.9) whereas B4C cut-off 1.2 was predictive of intracranial hypertension (AUROC 0.9, p < 000.1 for ICP > 20 mmHg). Conclusion: B4C provided biometric amplitude ratios correlated with ICPW variation morphology and is useful for noninvasive critical care monitoring.
Highlights
Continuous invasive intracranial pressure (ICP) monitoring is crucial for the management of intracranial hypertension (ICH) in the intensive care setting [1,2]
Noninvasive surrogates for ICP monitoring have been proposed, especially bedside techniques as pupillometry and ultrasound methods such as transcranial Doppler and optic nerve sheath measure have been applied for the assessment of intracranial compliance (ICC) [14,15,16,17]
The results of this study demonstrated a statistically significant correlation between the intracranial pressure waveform (ICPW) morphology parameters of the gold standard invasive ICP monitoring and the B4C
Summary
Sérgio Brasil 1, * , Davi Jorge Fontoura Solla 1 , Ricardo de Carvalho Nogueira 1 , Manoel Jacobsen Teixeira 1 , Luiz Marcelo Sá Malbouisson 2 and Wellingson da Silva Paiva 1.
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