A novel mutation in the α-helix 1 of the C subunit of the F 1/F 0 ATPase responsible for optochin resistance of a Streptococcus pneumoniae clinical isolate

Abstract

Previously reported mutations involved in optochin resistance of Streptococcus pneumoniae clinical isolates changed residues 48, 49 or 50, in the transmembrane α-helix 2 of the F 1/F 0 ATPase subunit. We report here an unusual mutation which changes the sequence of the transmembrane α-helix 1 of the AtpC subunit. This mutation involves a Gly to Ser substitution resulting from a G to A transition at codon 14 of the atpC gene.