Abstract
Background: We previously described a novel micronutrient blend that behaves like a putative calorie restriction mimetic. The aim of this paper was to analyze the beneficial effects of our micronutrient blend in mice and C. elegans, and compare them with calorie restriction. Methods: Whole transcriptomic analysis was performed in the brain cortex, skeletal muscle and heart in three groups of mice: old controls (30 months), old + calorie restriction and old + novel micronutrient blend. Longevity and vitality were tested in C. elegans. Results: The micronutrient blend elicited transcriptomic changes in a manner similar to those in the calorie-restricted group and different from those in the control group. Subgroup analysis revealed that nuclear hormone receptor, proteasome complex and angiotensinogen genes, all of which are known to be directly related to aging, were the most affected. Furthermore, a functional analysis in C. elegans was used. We found that feeding C. elegans the micronutrient blend increased longevity as well as vitality. Conclusions: We describe a micronutrient supplement that causes similar changes (transcriptomic and promoting longevity and vitality) as a calorie restriction in mice and C. elegans, respectively, but further studies are required to confirm these effects in humans.
Highlights
Calorie restriction (CR), the reduction in calories typically by 40–60%, is a major intervention consistently demonstrated to retard aging and delay age-associated diseases [1,2]
calorie restricted (CR) can be used as a model to understand healthy aging, but CR mimetics would be appealing, i.e., interventions that elicit positive cause effects that are similar to CR but without the drawbacks
The term CR mimetic was first used by Lane, Ingram and Roth of the National Institute on Aging in 1998 [21]
Summary
Calorie restriction (CR), the reduction in calories typically by 40–60%, is a major intervention consistently demonstrated to retard aging and delay age-associated diseases [1,2]. Recently there has been an increased focus on identifying CR mimetics, i.e., interventions including drugs, phytochemicals, vitamins, etc., that deliver the favorable effects of CR but without restricting macronutrient intakes, avoiding the above-mentioned drawbacks. Much of the focus in identifying CR mimetics has been on drugs that target metabolism and metabolic pathways. We previously described a novel micronutrient blend that behaves like a putative calorie restriction mimetic. The aim of this paper was to analyze the beneficial effects of our micronutrient blend in mice and C. elegans, and compare them with calorie restriction. Methods: Whole transcriptomic analysis was performed in the brain cortex, skeletal muscle and heart in three groups of mice: old controls (30 months), old + calorie restriction and old + novel micronutrient blend.
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