Abstract
BackgroundTo demonstrate that the Corvis ST could be used to quantify the biomechanical parameters of the orbital soft tissues by measuring and comparing whole eye movement (WEM) using the Corvis in normal eyes and in eyes of patients with Graves ophthalmopathy.MethodsForty four eyes of 44 ophthalmologically normal subjects and 28 eyes of 28 patients with Graves ophthalmopathy were included in the study. After Corvis test, the examiners recorded WEM by air puff. In the patients with Graves ophthalmopathy, the partial correlation coefficient adjusted for age and gender was calculated to analyze the correlation between exopthalmometry and WEM. Same analysis was repeated for the correlation between and the cross sectional area (%) of the extraocular muscles in the orbit CT and WEM.ResultsWEM was 0.314 ± 0.083 mm in the normal subjects and 0.227 ± 0.079 mm in the Graves ophthalmopathy group (p = 0.000). The exophthalmometry was not significantly correlated with WEM after adjusting for age and gender (R = 0.083, p = 0.688). In the 21 Graves ophthalmopathy patients examined by orbit CT, after adjusting for age and gender, WEM significantly decreased as the cross sectional area (%) of the extraocular muscles in the orbit increased (R = − 0.461, p = 0.047).ConclusionsWEM by Corvis could be used to quantify the biomechanical parameters of the orbital soft tissue. However, it is unclear whether WEM effectively represents the orbital biomechanical parameters, because WEM is only 0.6% of the orbital depth.
Highlights
To demonstrate that the Corvis ST could be used to quantify the biomechanical parameters of the orbital soft tissues by measuring and comparing whole eye movement (WEM) using the Corvis in normal eyes and in eyes of patients with Graves ophthalmopathy
WEM was significantly smaller in the Graves ophthalmopathy group compared with the normal group (Mann Whitney U-test, p = 0.000)
Relationship with age and gender In the normal group, WEM was significantly positively correlated with age (Spearman correlation coefficient r = 0.531, p = 0.000, Fig. 3)
Summary
To demonstrate that the Corvis ST could be used to quantify the biomechanical parameters of the orbital soft tissues by measuring and comparing whole eye movement (WEM) using the Corvis in normal eyes and in eyes of patients with Graves ophthalmopathy. The recently developed corneal dynamic scheimpflug analyser (Corvis ST; Oculus, Wetzler, Germany) is a diagnostic instrument comprising a noncontact tonometer, a Scheimpflug geometry, and an ultra-high speed camera that can measure intraocular pressure and corneal biomechanical parameters. When the cornea reaches maximum displacement, the whole eye motion becomes more pronounced and nonlinear in nature, as the air puff pressure continues to increase to a consistent maximum. The authors hypothesized that we could use the Corvis ST to quantify the biomechanical parameters of the orbital soft tissue behind the eyeball based on the eyeball displacement during the air puff. If the orbital soft tissues, such as the fat and extraocular muscles, change, we would expect that eyeball displacement would change
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