Freshwater is the key resource for the continuation of human society. With the growth of world population, the world water consumption has been increasing exponentially in the past decades [1, 2]. Humidification-dehumidification (HDH) processes and membrane distillation (MD) are two emerging technologies that are suitable for smallscale operation Both processes are facing key challenges that should be overcome before wider application is possible. MD are facing the issues of small distillate flux, membrane degradation due to scaling and fouling, and relatively low thermal efficiency. The spray-assisted low-temperature desalination (SLTD) technology is a recently proposed method that mitigates the issues faced by conventional thermal processes. It employs direct-contact evaporation/condensation method, eliminating metallic surfaces inside the system. A cost analysis will be conducted to evaluate the economic viability of the proposed configuration