Abstract
Iodine sets allenes ringing: A novel iodine-promoted tandem cyclization reaction of but-2-yne-1,4-diol and 4-aminobut-2-yn-1-ol derivatives leading to substituted 3,4-diiodoheterocyclic compounds has been developed (see scheme). In this reaction, a trace amount of water is needed. Both the iodine anion and cation generated from I2 are used in the reaction. The resulting iodides can then be used in palladium-catalyzed coupling reactions. The reaction conditions are metal-free, mild, and environmentally friendly.
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