A Novel Autonomous Molecular Mechanism Based on Spatially Localized DNA Computation

Abstract

Contemporary DNA synthesis technology matures, and the development provides intriguing possibilities for dynamic manipulation of DNA self-assembly, which plays a pivotal role in the behavior of designing versatile nanodevices and generating controllable networks. Similarly, in synthetic molecular circuits, the spatially localized architecture furnishes a different strategy, allowing for immobilized DNA molecules in close vicinity to each other. Herein, the formal modeling language was utilized to mark the address with a specific sequence of location tags, thus a set of routes were precisely arranged at the nanoscale. Beyond building a collection of separate modules, computer simulations were used to explore further complex assemblies of the building blocks. By orchestrating a series of DNA strand displacement operations locally, autonomous movement and addressing operations were realized, completing the group transport and partition storage of dissimilar molecules. The nanodevice gives the DNA molecule its mechanical properties and follows an embedded “molecular program”. The simulation results of the Visual DSD tool provided qualitative and quantitative proof for the operation of the system.