Abstract
This work presents the preparation of an efficient and sensitive glucose sensor for the detection of glucose in an alkaline media. The glucose sensor is composed of a metal organic framework (MOF) composite comprising Ag@TiO2 nanoparticles. The hybrid of Ag@TiO2 encapsulated in ZIF-67 was synthesized by the solvothermal method and applied onto a glassy carbon electrode (GCE) for the non-enzymatic sensing of glucose. The porosity of ZIF-67 was favorable for the unhindered diffusion and entrapment of glucose and its cavities served as reaction vessels. The electrochemical behavior of Ag@TiO2@ZIF-67 showed amplified results when compared with that of Ag@TiO2 and ZIF-67. Cyclic tests toward the oxidation of glucose has demonstrated excellent stability of a MOF-based hybrid sensor. The sensor based on Ag@TiO2@ZIF-67 showed high sensitivity of 0.788 μAμM−1cm−2 with a linear concentration range of 48 μM−1 mM and a response time of 5 s with an excellent detection limit of 0.99 μM (S/N = 3).
Highlights
Diabetes mellitus is a very common and fatal disease
In the case of Ag@TiO2@ZIF-67 (Figure 1A), all the diffraction peaks for ZIF-67 could be seen after the successful addition of Ag@TiO2, demonstrating retention of ZIF-67 crystal structure in the nanocomposite
It can be assumed that the addition of Ag NPs in the metal organic framework (MOF) has no effect on its crystal structure
Summary
Sensor for Glucose Detection Based on Ag@TiO2@ Metal-Organic Framework (ZIF-67) Nanocomposite. This work presents the preparation of an efficient and sensitive glucose sensor for the detection of glucose in an alkaline media. The glucose sensor is composed of a metal organic framework (MOF) composite comprising Ag@TiO2 nanoparticles. The hybrid of Ag@TiO2 encapsulated in ZIF-67 was synthesized by the solvothermal method and applied onto a glassy carbon electrode (GCE) for the non-enzymatic sensing of glucose. Cyclic tests toward the oxidation of glucose has demonstrated excellent stability of a MOF-based hybrid sensor. The sensor based on Ag@TiO2@ZIF-67 showed high sensitivity of 0.788 μAμM−1cm−2 with a linear concentration range of 48 μM−1 mM and a response time of 5 s with an excellent detection limit of 0.99 μM (S/N = 3)
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