Abstract
In this issue of the Biophysical Journal, Nygaard et al. (1) describe an exciting new solid-state NMR approach to probe the composition of whole bacterial cells and their cell-wall fractions. Use of uniform 13C and 15N labeling as well as magic-angle spinning and rotational-echo double-resonance (REDOR) selection of either Gly or non-Gly 13C signals allows for NMR detection of many chemical functionalities including polysaccharide and protein (2–5). In my view, the most exciting result is the striking differences among unfiltered 13C NMR spectra of whole bacterial cells grown with different antibiotics, as displayed in Fig. 7 in the article.
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