Abstract
A phytochemical investigation of the anomalous fruits of Gleditisia sinensis led to one new oleanane-type triterpenoid saponin acylated with one monoterpenic acid, 3-O-β-D-glucopyranosyl oleanolic acid 28-O-β-D-xylopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 2)-[(6S,2E)-6-hydroxy-2,6-dimethyl-2,7-octadienoyl-(1 → 6)]-β-D-glucopyranosyl ester, named gleditsioside Z (1), together with nine known ones (2–10). Their structural details were mainly established on the basis of 1D, 2D NMR and HR–MS analysis as well as some chemical methods. Structure–activity relationships of the isolated saponins that affected nitric oxide production from cultured mouse macrophages (RAW 264.7 cell lines) induced by lipopolysaccharide were discussed.
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