Abstract
Background Postoperative cognitive dysfunction （POCD） is one of the most common perioperative complications. The γ-aminobutyricacid type A （GABAA） receptor, which is a type of inhibitory receptor in central nervous system, may play an important role on the development of POCD. Objective To review the effects of GABAA receptor related-drugs on POCD. Content GABAA receptor agonist, GABAA receptor antagonist and GABA_A receptor inverse agonist, may have effects of induction, inversion or improvement on POCD, respectively. Trend The GABAA receptor related -drugs may provide a new attractive therapeutic option for POCD, and it maybe a highlight of future research. Key words: Postoperative cognitive dysfunction; γ-aminobutyricacid type A receptor; γ-aminobutyricacid type Areceptor antagonist; γ-aminobutyricacid type A receptor agonist
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