Abstract
Phytochemical study of Rourea oligophlebia stems led to the isolation of a new 2-pyrrolidone alkaloid (R,S)-N-(5-hydroxyl-pyrrolidin-2-one-1-yl)acetamide (1), together with 14 known compounds including friedelin (2), friedanol (3), taraxerol (4), vanillin (5), coniferyl aldehyde (6), apigenin (7), 7α-hydroxy-3β-sitosterol (8), coniferyl alcohol (9), scopoletin (10), emodin (11), protocatechuic acid (12), catechin (13), procyanidin A1 (14), and (E)-2,3,5,4’-tetrahydroxystilbene-2-β-D-glucoside (15). Several isolated compounds were evaluated for cytotoxicity and antimicrobial activity. Compound 11 exhibited good antimicrobial activity on Gram (+) strains and moderate cytotoxicity against KB, Hep-G2, and LU cancer cell lines. Compounds 6 and 8–10 showed selective activity on HepG-2 and MCF-7 over KB and LU cancer cell lines, while compound 7 exhibited similar effects on KB, HepG-2, and MCF-7 cell lines with IC50 values of 36.46 ± 0.81, 32.00 ± 0.58, and 32.03 ± 0.61 µg/mL, respectively.
Highlights
Introduction e genus ofRourea is a group of climbing shrubs belonging to the family of Connaraceae which are widely distributed in the Amazon, Pacific region, Africa, and Asia [1]
We described the isolation and identification of a new pyrrolidone alkaloid (R,S)N-(5-hydroxyl-pyrrolidin-2-one-1-yl)acetamide (1) (Figure 1) and fourteen known compounds including friedelin (2), friedanol (3), taraxerol (4), vanillin (5), coniferyl aldehyde (6), apigenin (7), 7α-hydroxy-3β-sitosterol (8), coniferyl alcohol (9), scopoletin (10), emodin (11), protocatechuic acid (12), catechin (13), procyanidin A1 (14), and (E)-2,3,5,4’-tetrahydroxystilbene-2-β-D-glucoside (15) from the stems of R. oligophlebia (Figure S1). e isolated compounds were evaluated for antimicrobial activity and cytotoxicity
E known compounds were elucidated as friedelin (2), friedanol (3) [12], taraxerol (4) [18], vanillin (5), coniferyl aldehyde (6) [19], apigenin (7) [20], 7α-hydroxy-3β-sitosterol (8) [21], coniferyl alcohol (9) [22], scopoletin (10) [23], emodin (11) [24], protocatechuic acid (12), catechin (13) [25], procyanidin A1 (14) [26], and (E)-2,3,5,4’-tetrahydroxystilbene-2-β-D-glucoside (15) [27]
Summary
Introduction e genus ofRourea is a group of climbing shrubs belonging to the family of Connaraceae which are widely distributed in the Amazon, Pacific region, Africa, and Asia [1]. Chemical investigations have revealed that Rourea species contain a substantial number of biologically active constituents, including flavonoids, phytosteroids, triterpenes, lipids, phenolic acids, and coumarins [1,2,3,4,5,6]. A preliminary study of R. oligophlebia revealed the presence of triterpene, sterol, and phenolic constituents [12]. We described the isolation and identification of a new pyrrolidone alkaloid (R,S)N-(5-hydroxyl-pyrrolidin-2-one-1-yl)acetamide (1) (Figure 1) and fourteen known compounds including friedelin (2), friedanol (3), taraxerol (4), vanillin (5), coniferyl aldehyde (6), apigenin (7), 7α-hydroxy-3β-sitosterol (8), coniferyl alcohol (9), scopoletin (10), emodin (11), protocatechuic acid (12), catechin (13), procyanidin A1 (14), and (E)-2,3,5,4’-tetrahydroxystilbene-2-β-D-glucoside (15) from the stems of R. oligophlebia (Figure S1). We described the isolation and identification of a new pyrrolidone alkaloid (R,S)N-(5-hydroxyl-pyrrolidin-2-one-1-yl)acetamide (1) (Figure 1) and fourteen known compounds including friedelin (2), friedanol (3), taraxerol (4), vanillin (5), coniferyl aldehyde (6), apigenin (7), 7α-hydroxy-3β-sitosterol (8), coniferyl alcohol (9), scopoletin (10), emodin (11), protocatechuic acid (12), catechin (13), procyanidin A1 (14), and (E)-2,3,5,4’-tetrahydroxystilbene-2-β-D-glucoside (15) from the stems of R. oligophlebia (Figure S1). e isolated compounds were evaluated for antimicrobial activity and cytotoxicity
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