Abstract
SummaryBackgroundWe aimed to investigate the prognostic importance of platelet-lymphocyte ratio (PLR) and neutro - phil-lymphocyte ratio(NLR) combination for patients diagnosed with acute pancreatitis and its relationship with mortality.MethodsThis retrospective study was included 142 patients diagnosed with acute pancreatitis. Ranson, Atlanta and BISAP 0h, 24h and 48h scores of the patients were calculated by examining their patient files. The patients were divided into three groups as low-risk, medium-risk and high-risk patients according to their PLR and NLR levels.ResultsThe number of patients with acute pancreatitis complications such as necrotizing pancreatitis, acute renal failure, sepsis and cholangitis was significantly higher in the high-risk group compared to other groups. Mortality rate was found to be 90% in the high-risk group, 16% in the medium-risk group, and 1.9% in the low-risk group. The number of patients with a Ranson score of 5 and 6, a severe Atlanta score, a BISAP 0h score of 3 and 4, a BISAP 24h and 48h score of 4 and 5 was higher in the high-risk group compared to other groups. PLR-NLR combination, Atlanta and Ranson scores, and C-reactive protein level were determined to be independent risk factors predicting mortality in stepwise regression model. PLR-NLR combination had the highest area under curve value in terms of predicting acute claspancreatitis prognosis and had a similar diagnostic discrimination with other scoring systems.ConclusionIn our study it was found that PLR-NLR combination had a similar prognostic importance with other scoring systems used to determine acute pancreatitis prognosis.
Highlights
Acute pancreatitis is the sudden onset severe inflammation of pancreas and the most common cause of gastrointestinal hospitalization in the United States [1]
We have found studies in the literature suggesting that Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) could be used to predict prognosis of acute pancreatitis [11], there is not a study that compares the combination of these markers with C-reactive protein (CRP) and scores commonly used for pancreatitis prognosis such as Ranson, Atlanta, and bedside index for severity in acute pancreatitis (BISAP)
In this study, we aimed to investigate the prognostic importance of PLR-NLR combination for patients diagnosed with acute pancreatitis and its relationship with mortality
Summary
Acute pancreatitis is the sudden onset severe inflammation of pancreas and the most common cause of gastrointestinal hospitalization in the United States [1]. Determination of its prognosis is of vital importance Several scoring systems such as Ranson score [3], Atlanta classification [4], acute physiology and chronic health evaluation (APACHE)-2 [5], the bedside index for severity in acute pancreatitis (BISAP) [6], and laboratory parameters such as C-reactive protein (CRP) are used for this purpose. Inspite of all these scoring systems and laboratory parameters, it may still be difficult to determine its prognosis.
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