Abstract
AbstractBased upon Okusa's observation (Chem. Pharm. Bull. 1975) that the slopes of a linear plot of logo log fraction of active substance degraded vs log time for first order decay kinetics and a linear plot of log of drug remaining vs log time for a zero order decay kinetics are both unity, an algorithm has been developed to resolve both the energy of activation (E) and the rate constant (Ko or Lo) at the desired shelf-life temperature (To) by analysis of the y-intercepts of parallel slopes at more than one elevated temperature (T).Preliminary estimates of both E and either Ko or Lo are then substituted into a series of mathematical expressions based upon well known Arrhenius relationship:k = A ·exp -E/1.987) (1/T-l/To) where A = Ko or LoUsing converging and interative techniques to treat elevated temperature data, the resulting mean loss rate (eithri Ko or Lo at the designated shelf-life temperature plus a residual error term thus obtained, is used to distinguish statistically between zero and first or...
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