Abstract
Titanium and its alloys are widely used as implant biomaterials due to their well mechanical properties and biological compatibilities. Nb and Mn are well‐known alloying elements with biological potential. Herein, the Ti–Mn–Nb phase equilibria at 900 °C (Ti‐rich region) is determined and published. According to the β single‐phase field in this phase diagram (at 900 °C), Ti–xMn–yNb (x = 4, 10, 16; y = 2, 8, 14, at%) alloys are selected and fabricated which are suited for solution heat treatment. The Ti–Mn–Nb alloys are investigated by optical microscopy (OM), X‐ray diffraction (XRD), and mechanical testing. A unique diffraction pattern (interpreted as occurrence of a transition phase) is observed by transmission electron microscopy (TEM) in Ti–10Mn–2Nb. In the in vitro evaluation, the human osteoblasts (MG63) adhere well and proliferate on the surface of Ti–xMn–yNb (x = 4, 10; y = 2, 8, 14, at%). According to cell culture experiments, the alloys are nontoxic to human osteosarcoma cells in comparison with pure titanium. Based on a performed screening study, different titanium alloys Ti–4Mn–yNb (y = 2, 8, 14) appear as the biomaterial with the highest potential around 700 MPa ultimate tensile strength and 9–10% elongation.
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