Abstract
This study summarizes the Ph.D.-research project concerning the development of a new high water vapor permeable wound dressing. The dressing is composed of a 15 microns thin polyetherurethane (PEU) film, which has many non-interconnected cavities to enable a high water vapor permeability up to 20.1 g.m-2.h-1.kPa-1. Since only water vapor permeates through the PEU dressing, the wound exudate underneath is condensed into a gelatinous coagulum. Epithelialization was accelerated by 25% under the clot-permissive PEU film compared with the fluid retaining OpSite film. In clinical situations on donor sites and grafted full-thickness burn wounds, the PEU film indeed prevented fluid accumulation and induced the formation of a "red" coagulum underneath. It furthermore reduces pain significantly compared to conventional paraffin gauze dressing. In conclusion, the optimum environment for epithelialization is a wound, in which the exudate is permitted to gelatinize between moist and dry.
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