Abstract
Rats receiving intraventricular injection of 6-hydroxydopamine (6-OHDA) were housed in isolation for one month and placed in the same cage as an untreated rat while being subjected to continuous tail pinching. 6-OHDA-treated rats violently attacked the untreated rat and stabilized fighting between the two animals persisted for over 1 hr. The 6-OHDA-treated rats consistently played the dominant role in the dominant-subordinate relationship established between the rats. By allowing this fighting to continue for 1 hr, gastric erosion associated with severe hemorrhage occurred with a high incidence in the untreated rats. These erosions were comparable in rats examined immediately after fighting and in those examined after 1 hr and 3 hr. Poststress rest was not required for erosion to occur. The presence of bite wounds incurred during fighting was unrelated to the incidence of gastric erosion. In addition, it was unnecessary to fast the untreated rats beforehand. Based on these findings, the present model apparently does not rely on physical stimulation. These factors and the ease of its execution make the present new experimental model of stress ulcers very useful.
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