Abstract
The function of the ubiquitously expressed class IA phosphatidylinositol 3-kinase (PI3K) p110 catalytic subunit, which is frequently mutated in human cancers, has been delineated by a team of researchers led by Bart Vanhaesebroeck at the Ludwig Institute for Cancer Research, London, UK, and Dominic Withers at the University College London Centre for Diabetes and Endocrinology, UK. PI3Ks are a family of lipid kinases that are involved in signal transduction; the roles of most PI3K isoforms in both normal physiology and disease have remained elusive — until now.
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