Abstract
A new fungal strain, displaying strong toxic activity against brine shrimp larvae, was isolated from a deep sea sediment sample collected at a depth of 1300 m. The strain, designated as F00120, was identified as a member of the genus Penicillium on the basis of morphology and ITS sequence analysis. One new sesquiterpene quinone, named penicilliumin A (1), along with two known compounds ergosterol (2) and ergosterol peroxide (3), were isolated and purified from the cultures of F00120 by silica gel column, Sephadex LH-20 column, and preparative thin layer chromatography. Their structures were elucidated by detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analysis as well as comparison with literature data. The new compound penicilliumin A inhibited in vitro proliferation of mouse melanoma (B16), human melanoma (A375), and human cervical carcinoma (Hela) cell lines moderately.
Highlights
In recent years, marine microbes have received growing attention as the sources for bioactive metabolites
We describe the fungal strain F00120, which was isolated from a deep sea sediment sample and exhibited strong toxic activity against brine shrimp larvae
A fungal strain, F00120, which was isolated from a deep sea sediment sample collected in the northern South China Sea at a depth of 1300 m, displayed strong toxic activity against brine shrimp larvae
Summary
Marine microbes have received growing attention as the sources for bioactive metabolites. Marine fungi have shown promising potential to produce a broad variety of bioactive metabolites with novel structures, and so far have provided more than 1000 new natural products, including polyketides, alkaloids, terpenoids, peptides, prenylated polyketides, shikimate-derived metabolites, and lipids [6,7,8,9]. Of these new natural products, 16% were isolated from marine sediment-derived fungi. The new sesquiterpene quinone displayed moderate cytotoxic activity against mouse melanoma (B16), human melanoma (A375), and human cervical carcinoma (Hela) cells
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