Abstract
The possibility of substituting a nonradioactive isotope of chromium for 51Cr was studied. Blood, from five dogs with varying erythrocyte life spans, was labeled with 50Cr and 51Cr and transfused autologously. Erythrocyte-bound 50Cr was determined by inductively coupled argon plasma mass spectrometry and 51Cr by measuring radioactivity. Erythrocyte life span determination derived from the two isotopes did not differ significantly. Our results suggest that 50Cr can provide a nonradioactive alternative to 51Cr for labeling erythrocytes for life span studies.
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