Abstract
Inflammation is a complex physiological response involving various cellular and molecular events. Sulfur dioxide (SO2), which is usually in the form of HSO3- and SO32- under physiological conditions, plays a crucial role in the regulation of inflammation and diseases. Frequency upconversion luminescence (FUCL) can realize the unique anti-Stokes process of long-wavelength excitation to short-wavelength emission; thus, it is a highly promising optical method for in vivo imaging due to its deep tissue penetration, low photo-damage, etc. Therefore, we developed a near-infrared FUCL NIRX-1 probe for the detection of HSO3-. NIRX-1 had a fast response (80 s), a low detection limit (0.43 μM), and high selectivity towards HSO3-. In addition, NIRX-1 had deep light penetration ability due to the near-infrared excitation at 808 nm and was able to detect HSO3- in living cells and mice. Lastly, NIRX-1 was employed in the imaging of HSO3- in an inflammation mouse model through FUCL imaging techniques. All these features make NIRX-1 a good candidate for the investigation of SO2-associated physiological and pathological processes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
