Abstract
Cellular mechanical stimulators with multiplexing and high-throughput capability often use multiple external pumps, which compromise simplicity and miniaturization. In this study, we report a bilayered microfluidic device driven by one single pump to deliver in-plane surface strains toward four membranes with proportional center strain magnitudes. The maximal strain magnitudes exhibited a constant proportionality (i.e., 1:2:3:4) under both static and dynamic loading conditions. The influences of the loading frequency and the total membrane number were examined. Proof-of-concept cell loading showed that the device can be used to investigate magnitude-dependent cell responses to mechanical stimuli, thus promising broad applications in cell mechanobiological studies where delivery of mechanical signals with controlled and varying magnitudes toward multiple loading sites is needed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
