Abstract
Drug delivery is the technique or method of administering a pharmaceutical compound to earn a more satisfactory therapeutic impact for human diseases. Based on the good characteristics (high surface area, high capacity for loading a drug and high biological compatibility and degradability) of the graphene nanoparticles, they are widely used in medicine, particularly drug delivery. Hence, in this research, a two-dimensional graphene sheet as a nanocarrier and Gemcitabine (GEM) as chemotherapy have been used to form a (graphene/GEM) system. Moreover, the interactions between the nanocarrier and GEM molecule were explored via Molecular Dynamics (MD) simulation. To investigate the interaction between GEM and graphene, the dynamics of GEM molecule, radial distribution function (RDF), root mean square deviation (RMSD), radius of gyration (Rg), and solvent-accessible surface area (SASA) parameters are analyzed. Results indicate that GEM on the graphene has a more stable structure in comparison with the free GEM molecule. Therefore, the graphene/GEM system can be considered a useful therapeutic system for cancer treatment with minimum side effects.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
