A miniaturized wireless micro-heating strip integrated with an acrylate-composite temperature regulator for restenosis prevention

Abstract

• This work presents aminiaturized wireless heating strip with novel temperature regulator forwireless hyperthermia treatment. • The proposed device employs an acrylate-based composite which is critical for achieving smooth regulation of temperature. • The resonant methodoffers high frequency selectivity and high efficiency in wireless heating. • The temperature regulator enables the capability of heating regulation in a passive manner, reducing the complexity of the device, and thus further facilitates the miniaturization of the device. This work proposes a miniaturized wireless heating strip designed for safe wireless hyperthermia treatment against restenosis. The proposed heating strip was designed to be inserted into a stent that can be deployed in a blood vessel using a typical catheter-based delivery system. The device consists of a micromachined LC-based resonator and a microheater with a temperature regulator (MHTR). The LC-based resonator was employed to achieve wireless resonant RF heating, with the embedded MHTR serving as an electric current breaker in the resonator circuit to maintain the strip’s temperature within a desired range. An acrylate-based composite was used as the key material of the MHTR for temperature sensing and electric-current breaking. The MHTR allows smooth heating regulation in a passive manner, reducing the complexity of the device, and thus further facilitates the miniaturization of the device. The frequency responses to temperature of devices with and without an MHTR were studied. The performance of devices immersed in physiological saline solution was also examined in detail. Wireless heating tests demonstrated that the proposed MHTR effectively maintained the device temperature at around 45 °C with an output RF power of 500 mW. The results indicate that the proposed device potentially offers safe and reliable hyperthermia treatment.