Abstract
In the musculoskeletal system, stem cells generating musculoskeletal enveloping tissues, such as synovial joints, periosteum, and muscle fascia, remain poorly understood. Broadly, the lineage correlation among these stem cells and those generating osteogenic and growth plate cells inside the bone is also elusive. Here we identify a migratory, periarticular stem cell population enriched by transcriptional factor NFATc1 (named N1-SSCs), which contributes to the formation of all musculoskeletal enveloping tissues and moves into the bone generating partial growth plate and osteogenic cells and strikingly the bone-resorbing osteoclasts too. Beyond development, NFATc1 also characterizes adult joint, fascial, and periosteal progenitors in mice and humans. Transcriptome analysis reveals the molecular signatures of N1-SSCs including numerous genes related to skeletal system development and cell migration. Functionally, NFATc1 controls chondrogenesis from N1-SSCs through restricting COL2A1 gene transcription. Our data support an invasion model of musculoskeletal stem cell patterning and uncover a non-hematopoietic origin of osteoclasts.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
