A Metronidazole-Modeled Central Composite Design Strategy for Plantago ovata Seed Mucilage-Supported Floating Microspheres for Helicobacter pylori Eradication

Abstract

Background of the research and the purpose: Instead of using costly synthetic excipients or polymers, the authors were in search of an economical, easily available, and plant-based excipient for making microspheres. Plantago ovata seeds have already been proven to have anti-ulcer and gastro-protective activity. The same mucilage is used in this study as a polymer that can aid in floating the microspheres. In this study, mucilage from Plantago ovata seeds was added to sodium alginate and used with Metronidazole as a treatment to eradicate Helicobacter pylori. Methodology: Plantago ovata seed mucilage (POSM) and sodium alginate were used to make microspheres. To check the effects of independent variables (POSM and SA levels) on entrapment efficiency (EE) and floating time (FT) as responses, this paper used a central composite design with a design expert.11 software. The microspheres were investigated for Metronidazole (MNZ) content, size, yield, buoyancy, and release during congeniality studies. Results: As POSM content increased in the microspheres, MNZ entrapment increased, and the floating time (FT) was greater in microspheres with more POSM. MNZ release was slightly reduced in microspheres with higher levels of POSM. Conclusion: According to the investigation, MNZ can be retained in the stomach for extended periods of time in order to eradicate H. pylori, and the floating assets were enhanced by POSM.