Abstract
A micromethod suitable for measuring the combined blood levels of allopurinol and alloxanthine has been developed. The two compounds display marked inhibition of xanthine oxidase activity (Ki=6.3×10−10 and 5.4×10−10 M), so the amounts found in 20 µl serum from allopurinol-treated patients can cause marked inhibition of xanthine oxidase activity in vitro under appropriate conditions. If the concentrations of compounds acting in an ‘allopurinol-like’ manner are expressed in terms of allopurinol, activity equivalent values are obtained which reflect the effective drug concentration during therapy. The procedure is simple and suitable for serial examinations. It also satisfies the demands of the clinician, in that it can reveal any disturbance in the absorption of allopurinol and in excretion of the drug and its active metabolite, alloxanthine.
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