Abstract
The brains in patients with Alzheimer's disease show chronic inflammatory responses characterized by activated glial cells and increased expression of cytokines. It is of interest to determine whether acetylcholine (ACh) affects Aβ-induced cytokine expression in the glial cells. Since it has been shown that α7 subunits of nicotinic ACh receptors are expressed in glial cells and that Aβ 1–42 binds to α7, we examined the effects of cholinergic agonists, carbachol, nicotine and oxotremorine-M, on Aβ-induced TNF-α expression in mouse glial cells. We did not observe any regulatory effects of ACh on Aβ-induced TNF-α transcription in the glial cells. We discuss the pathophysiological roles of ACh in glial cells in the brains of patients with Alzheimer's disease.
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