Abstract
THE metabolic processes of the body are governed by compensating checks and balances which are frequently interdependent, some accelerating, some inhibiting specific processes. Among the most extensively studied of these activities is that of the factors, affecting carbohydrate metabolism. Insulin has, of course, been long known to be of prime importance to this process, but investigations have suggested that another substance obtained from the pancreas may also play a role in sugar metabolism. This substance has been found to produce hyperglycemia and increase the rate of hepatic glycogenolysis. There is at present no direct proof that the pancreatic hyperglycemic factor is functional under physiologic conditions. Results of cross-circulation experiments by Weinstein, Smith and Foa (1) have suggested that this may be true, but further observations are deemed necessary. Certain other evidence, both clinical and experimental, strongly supports this possibility and shall be briefly discussed at this time.
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