Abstract
A series of novel 3-(2-chloroquinolin -3- yl)acrylic acid derivatives (3a-j) were prepared by Knoevenagal condensation of 2-chloro 3-formyl quinoline (2a-j) with malonic acid (2) in the presence of catalytic quantity of pyridine under microwave irradiation in excellent yield with short time span (70 s). Newly synthesized compounds were characterized by IR, 1 H NMR and mass. activity 17 . Derivatives of 3-(quinolin-3-yl)acrylates and the corresponding reduced allylic alcohols that have been identified by Bristol-Myers Squibb (BMS) as novel and potent maxi-K channel openers useful for the treatment of male erectile dysfunction 18 . Due to such a wide range of applicability in medicinal field, there is increasing interest in the development of efficient methodologies for the synthesis of quinoline derivatives. The main objective of the present investigation is to provide the synthesis of some novel substituted 3-(2-chloroquinolin-3-yl)acrylic acid. The Knoevenagel condensation is one of the most effective synthetic method for the synthesis of several important key products that include unsaturated acids and unsaturated ester intermediates employed in the synthesis of several therapeutic drugs (e.g. Niphendipine
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