Abstract
Several genome-wide association studies (GWASs) have reported the association between genetic variants and the habitual consumption of foods and drinks; however, no association data are available regarding the consumption of black tea. The present study aimed to identify genetic variants associated with black tea consumption in 12,258 Japanese participants. Data on black tea consumption were collected by a self-administered questionnaire, and genotype data were obtained from a single nucleotide polymorphism array. In the discovery GWAS, two loci met suggestive significance (p < 1.0 × 10−6). Three genetic variants (rs2074356, rs144504271, and rs12231737) at 12q24 locus were also significantly associated with black tea consumption in the replication stage (p < 0.05) and during the meta-analysis (p < 5.0 × 10−8). The association of rs2074356 with black tea consumption was slightly attenuated by the additional adjustment for alcohol drinking frequency. In conclusion, genetic variants at the 12q24 locus were associated with black tea consumption in Japanese populations, and the association is at least partly mediated by alcohol drinking frequency.
Highlights
Black tea, which is derived from the Camellia sinensis plant, is one of the most widely consumed beverages in the world owing to its several beneficial compounds, including polyphenols, amino acids, vitamins, and minerals
It is crucial to accumulate data from genome-wide association studies (GWASs) to identify the relationship between genetic variants and dietary habits
This study performed a GWAS to search for genetic variants associated with the habitual consumption of black tea in 12,258 Japanese participants
Summary
Black tea, which is derived from the Camellia sinensis plant, is one of the most widely consumed beverages in the world owing to its several beneficial compounds, including polyphenols, amino acids, vitamins, and minerals. Genome-wide association studies (GWASs) have been conducted to investigate the association between genetic variants and the habitual intake of foods and drinks [6,7]. Nutrients 2020, 12, 3182 identified the association of genetic variants with the intake frequency of fish [8], alcohol consumption [9,10,11], and coffee consumption [12,13,14]. Dietary trait-associated genetic variants were linked to health outcomes in Japanese populations [7]. It is crucial to accumulate data from GWASs to identify the relationship between genetic variants and dietary habits. No data are available regarding black tea consumption-related genetic variants in individuals of other ethnicities, including Asian, European, and American. This study performed a GWAS to search for genetic variants associated with the habitual consumption of black tea in 12,258 Japanese participants
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