Abstract
Publisher Summary This chapter reviews four separate measures of genetic relatedness among the members of the Enterobacteriaceae and related genera that have been considered. First, transfer of genetic elements can occur in intercrosses within the entire group. However, integration of chromosomal genes from escherichia coli occurs with high frequency into the chromosome of shigella, with much reduced frequency into salmonella typhimurium, and is generally undetectable into other genera of the group. Second, DNA–DNA or DNA–RNA hybridization methods indicate that E. coli and shigella are closely related, while other genera are much less related to E. coli. Third, the linkage map is a conservative character, which is relatively unaltered in the genera escherichia, salmonella, and klebsiella, and may be similar in the entire family, while there is no evidence of similarity to the linkage maps of unrelated groups, such as bacillus and pseudomonas, to which transfer does not occur. Fourth, amino acid sequences of tryptophan synthetase reveal that these proteins in E. coli and S. typhimurium are related, but with a significant number of amino acid differences.
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