A fuzzy inference system for detection of obstructive sleep apnea

Abstract

A fuzzy inference system (FIS) was developed to detect obstructive sleep apnea (OSA) by analyzing the respiratory airflow signal in adults. The parameters analyzed were the normalized area and the standard deviation of consecutive 3-second intervals of baseline adjusted and rectified airflow signal. Fuzzy logic was used to process these parameters to detect apnea and hypopnea when the output values were within a specified range extracted from OSA patient data. The FIS comprised of three major stages of computation: fuzzification, fuzzy rule evaluation and defuzzification. Seven males and two females with an average age of 48 years (range: 26 - 66 years), an average weight of 102 kg (range: 63 - 159 kg), an average height of 1.7 m (range: 1.5 - 1.8 m) and an average body mass index (BMI) of 33 kg/m/sup 2/ (range: 21 - 42 kg/m/sup 2/) participated in this study. Patients spent at least 8 hours in an accredited sleep laboratory. However, patient data was collected for only part of this time. The total amount of test time for all nine patients was 38.83 hours with an average of 4.31 hours/patient (range: 1.92 - 7.63 hours). The total number of apnea events occurring during this time was 808, and the number of hypopnea events was 694. The membership functions for the FIS were derived by analyzing apnea and hypopnea events in four patients. The data from all nine patients were used in algorithm performance evaluation. The apnea and hypopnea events were scored by a sleep specialist and were used to test the correct detection rate by the FIS. The results demonstrated that the FIS reached an overall correct detection rate of 83% across all patients. The false negative rate was 17% and the false positive rate was 12%. The correct detection rate varied from patient to patient and correct rates greater than 90% were achieved in three patients. This study suggests that fuzzy inference could provide an intelligent algorithm for control of a continuous positive airway pressure (CPAP) machine. It would detect apnea and hypopnea events and automatically adjust the pressure to eliminate them. The performance of the algorithm could be further optimized to give increased detection rates. This could be achieved by performing further studies on a larger OSA patient population and utilizing augmentative methods such as neural networks to better sense the fuzzy patterns in the OSA data.