Abstract
A highly sensitive and selective Hg2+ probe 4 based on rhodamine-b was developed and characterized. In consideration of environmental and biological application, we connected a water soluble receptor group (sulfonated β-naphtol) and rhodamine-b together through hydrazine hydrate in high yield. The result turns out that this compound not only exhibits excellent sensitivity and selectivity toward Hg2+, but also shows well cell permeability and compatibility in vitro.
Highlights
Nowadays, classic detection methods, such as spectrophotometry, atomic absorption spectrometry, inductively coupled plasma-mass spectroscopy (ICP-MS), inductively coupled plasma-atomic emission spectrometry (ICP-AES) and voltammetry, can hardly meet the new challenge of social development
Cheap chemical sensors with high sensitivity and selectivity that could be utilized in environmental system and biological system are explored with great attention [1]
Due to the excellent photo-physical properties, such as high fluorescence, large absorption coefficient, long absorption and emission wavelength [2], rhodamine based fluorescent chemosensors have attracted the attention of an increasing number of people [3,4,5]
Summary
Classic detection methods, such as spectrophotometry, atomic absorption spectrometry, inductively coupled plasma-mass spectroscopy (ICP-MS), inductively coupled plasma-atomic emission spectrometry (ICP-AES) and voltammetry, can hardly meet the new challenge of social development. In our previous work [40], we have already achieved a “turn-on” type fluorescent chemosensor toward Hg2+ based on rhodamine-b with high sensitivity and selectivity It showed excellent biological applications in living cells. In order to overcome this shortcoming, we combined a water soluble receptor group (sulfonated β-naphtol) and chromophore group (rhodamine-b) together and achieved a new compound (4) on the premise of maintaining its fluorescent sensitivity and selectivity toward Hg2+. This probe features high sensitivity and selectivity toward Hg2+ over other ions and reaches as low as 4 ppb of detection limit in methanol. The outstanding cell permeable and compatible characters confirm that this kind of Hg2+ probes has great potential in biological system and pharmacological system
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