Abstract
Summary A surgical patient, who was a carrier of a methicillin-resistant strain of Staphylococcus aureus , subsequently developed post-operative wound infections with the same strain. Treatment with a combination of gentamicin and fusidic acid resulted in the Staph. aureus becoming resistant to both of these drugs. The patient died with infection as a major contributory factor. Studies with the strain suggested that it was sensitive to flucloxacillin. Minimum inhibitory concentration (MIC) tests of a further 100 methicillin-resistant strains of Staph. aureus showed that only two per cent of strains were resistant to flucloxacillin and 19 per cent to cloxacillin. It is suggested that testing strains for sensitivity to methicillin does not necessarily represent their sensitivity to other penicillinase-resistant penicillins.
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