Abstract
2-amino-4,6-diarylpyrimidine (1mmol) (1) and methyl 2-(benzoxazoylsulfonyl) acetate were irradiated in an ultrasonic bath at a low frequency of 35 kHz at room temperature to synthesize a variety of benzazolysulfonyl primidinyl acetamide derivatives. As a result of the antibacterial activity examined, the substances were highly potent towards Gram-positive bacteria (S. aureus and B. subtilis) compared to Gram-negative bacteria (S. aureus & B. subtilis and P. aeruginosa & K. pneumoniae), respectively. Compounds with electron-withdrawing groups 15c, 15e, 16c, and 16e showed superior antibacterial and antifungal activity against B. subtilis and A. niger compared to conventional medications, chloramphenicol, and ketoconazole, with MICs of 6.25 µg/ml that were comparable to those of the conventional medications.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
