Abstract
An efficient two-component domino reaction strategy has been developed for the synthesis of 2,6-dicyanoaniline and 3-amino-9,10-dihydrophenanthrene-2,4-dicarbonitrile derivatives in moderate to good yield by the reaction between malononitrile and β-chloro-α,β-unsaturated aldehydes catalyzed by potassium hydroxide-18-crown-6 in methanol. In-vitro intercalation studies of 3-amino-9,10-dihydrophenanthrene-2,4-dicarbonitriles with Calf-Thymus DNA have been carried out which reveal that the moiety interacts with an affinity greater than that of ethidium bromide (EtBr).
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