Abstract
A coumarin-based dual responsive fluorescent probe with a simple structure was developed for the detection of Cys and HSO3−. Under simulated physiological conditions, Cou-F displayed an on–off fluorescence response to Cys at 521 nm and an off–on fluorescence response to HSO3− at 500 nm. Furthermore, Cou-F had the advantages of high sensitivity, strong specificity and rapid response. The detection limits of Cou-F toward Cys and HSO3− were 0.54 μM and 0.65 μM, respectively. Cou-F enabled high selective responses to Cys and HSO3− over other biologically related species. The response times of Cou-F toward Cys and HSO3− were 80 s and 100 s. The fluorescence imaging of Cys and HSO3− was achieved in living RAW246.7 cells.
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