Abstract
Reactive oxygen species (ROS) controls several physiological processes, including phagocytosis and pathogen destruction. Thus, it is necessary to developed reliable and effective tools to detect them. Here, in this work, we synthesized the first fluorescent probe (HR-SN) for dual-oxidant detection with quick, sensitive, and specific identification of •OH and HOCl in an aqueous solution. This probe contains a thiomorpholine group for detecting HOCl and an acetyl group that serves as the recognition site for the detection of hydroxyl radicals. HR-SN exhibits a distinct increase in fluorescence when exposed to •OH and HOCl, with a significant Stokes shift, rapid responses, and high sensitivity. The biological imaging results demonstrate that the probe is suitable for fluorescence imaging of living cells and living zebrafish. We anticipate that the concept and design outlined in this study could be a valuable reference for constructing fluorescence probes to detect reactive ROS for analytical and medical applications.
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