Abstract
Objectives: This study was conducted to identify and report the adverse drug reactions (ADRs) which are occurring in pediatric and medicine departments in a tertiary care hospital at Vadodara. Methods: A cross-sectional study was conducted for 6 months in-patient at a tertiary care teaching hospital. We enrolled the patients based on inclusion criteria and data was analyzed with the help of MS excel 7 and Graph pad Prism. Further, the assessments of type, severity, and preventability of reported ADRs were done using Wills and Brown classification, modified Schumock and Thornton severity scale, modified Hartwig and Siegel preventability scale. Results: Data were collected from a total of two hundred patients of which twenty-six (13%) patients were affected with ADRs. Among twenty-six patients, females (64%) were more affected with ADRs when compared to males (36%). According to the department, most ADRs were observed in the medicine ward than in the pediatric. The highest number of ADRs was associated with antibiotics (46.1%). Based on the type of ADRs, Type B ADRs (77%) were more observed followed by Type A (7%) and Type C (8%). Conclusions: The information obtained from our study will help clinical pharmacists and healthcare professionals to take precautions in the future and adopt certain measures for preventing the ADRs and hence help in promoting safer and rational drug use in institutions and improving the quality of patient care.
Highlights
The World Health Organization (WHO) defines adverse drug reactions (ADRs) as any response to a drug that is noxious and unintended, and which occurs at doses normally used in man for prophylaxis, diagnosis or therapy of disease, or the modification of physiologic function
Safety and efficacy are the major concerns of healthcare professionals when it comes to rational drug therapy and this is because it is common to find unwanted effects such as adverse reactions and side effects in every drug
ADRs were found more in the medicine department compared to the pediatric ward, i.e., Out of 26 patients, seven patients were of the pediatric department and 19 patients of medicine ward and the findings were significant *p=0.0352
Summary
The World Health Organization (WHO) defines adverse drug reactions (ADRs) as any response to a drug that is noxious and unintended, and which occurs at doses normally used in man for prophylaxis, diagnosis or therapy of disease, or the modification of physiologic function. ADRs have been considered as a leading cause of considerable morbidity and mortality. Safety and efficacy are the major concerns of healthcare professionals when it comes to rational drug therapy and this is because it is common to find unwanted effects such as adverse reactions and side effects in every drug. Apart from these, drug interactions between different kinds of medications contribute to the added concern of safety and efficacy of drug therapy. To avoid such unwanted effects of drug therapy health care professionals should practice the use of the best and safest medicines according to individual patient requirements [1]
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