Abstract
Dopamine (DA) is a critical neurotransmitter and has been known to be liable for several neurological diseases. Hence, its sensitive and selective detection is essential for the early diagnosis of diseases related to abnormal levels of DA. In this study, we reported novel molybdenum nanoparticles self-supported functionalized multiwalled carbon nanotubes (Mo NPs@f-MWCNTs) based core-shell hybrid nanomaterial with an average diameter of 40–45 nm was found to be the best for electrochemical DA detection. The Mo NPs@f-MWCNTs hybrid material possesses tremendous superiority in the DA sensing is mainly due to the large surface area and numerous electroactive sites. The morphological and structural characteristics of the as-synthesized hybrid nanomaterial were examined by XRD, Raman, FE-SEM, HR-TEM, EDX. The electrochemical characteristics and catalytic behavior of the as-prepared Mo NPs@f-MWCNTs modified screen-printed carbon electrode for the determination of DA were systematically investigated via electrochemical impedance spectroscopy, cyclic voltammetry, and amperometry. The results demonstrate that the developed DA biosensor exhibit a low detection limit of 1.26 nM, excellent linear response of 0.01 µM to 1609 µM with good sensitivity of 4.925 µA µM−1 cm−2. We proposed outstanding appreciable stability sensor was expressed to the real-time detection of DA in the real sample analysis of rat brain, human blood serum, and DA hydrochloride injection.
Highlights
Dopamine (DA, 3,4-dihydroxyphenylalanine) is a catecholamine neurotransmitter, which plays an important biological role in human metabolism, cardiovascular, central nervous, renal, and hormonal systems[1]
The XRD pattern of molybdenum nanoparticles (Mo NPs)@f-multiwalled carbon nanotubes (MWCNT) featured with peaks at 27.2°, 40.1°, 54.2°, and 74.2° corresponding to the lattice planes of (002), (110), (200), and (211), respectively
The XRD pattern of Mo NPs@f-MWCNTs is consistent with the characteristic pattern of Mo nanoparticle (ICDD cards No of 89-5023) as well as it included with the characteristic band of f-MWCNTs37,39
Summary
Received: 16 October 2018 Accepted: 1 August 2019 Published: xx xx xxxx material based non-enzymatic biosensor for electrochemical detection of dopamine neurotransmitter in biological samples. We reported novel molybdenum nanoparticles selfsupported functionalized multiwalled carbon nanotubes (Mo NPs@f-MWCNTs) based core-shell hybrid nanomaterial with an average diameter of 40–45 nm was found to be the best for electrochemical DA detection. In this study, a core-shell hybrid nanomaterial of Mo NPs@f-MWCNTs was successfully synthesized by acid condensation method and used to detect DA electrochemically for the first time. The as-prepared Mo NPs@f-MWCNTs was employed as the excellent electrocatalytic material for the detection of DA in both buffer and biological samples. SPCE was allowed to dry in air at room temperature, followed by gently dipped with buffer solution for twice to remove the unbound material prior to further electrochemical measurements and a similar procedure was adhered to prepare control electrode (f-MWCNTs)
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