Abstract
We revisit our earlier extension of the CRM and introduce a new version of the dose escalation procedure. Its performance is assessed by simulation, with respect to a template of five operating measures BEARS (Benchmark, Efficiency, Accuracy, Reliability, Safety) that was used in Zhang, Wang and Yang. Our goal is to correctly identify the maximum tolerated dose with a high probability while protecting trial subjects from undue risk of toxicity. Simulation results show that this may be achieved for some considered scenarios, selective models, and considered competing designs. We discuss the pros and cons of the new version of the dose escalation procedure in the face of treatment versus experimentation dilemma.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Communications in Statistics - Simulation and Computation
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
