Abstract
The core fragment C7-C15 the (+)-migrastatin was constructed in a stereoconvergent manner utilizing desymmetrization approach. The strategy involved the generation of Z-configuration of trisubstituted double bond at C11-C12, epimerization at C10, ring opening of the pyran lactol with C2 Wittig ylide, and regioselective Sharpless dihydroxylation.
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