Abstract
BackgroundVitiligo is a non-congenital skin disease caused by the vanishing of pigment cells from the epidermis. This disease is characterized by white patches, which are mostly spread in a symmetrical manner. The absence of melanin pigments makes the lesional skin increasingly sensitive to sunburn. Vitiligo can damage the beauty of skin and, being a trashing condition, predispose to psychological diseases. It happens in roughly 0.5% of the population around the world and equally in both men and women. The etiopathology of vitiligo remains unknown; however, it may involve hereditary factors, autoimmunity, neurological diseases, poisonous metabolites, and impaired melanocyte development. Different treatments such as herbal treatment, surgery and new drug delivery systems for vitiligo have been proposed. PurposeThis review is going to deal with all the previously mentioned diseases with vitiligo pathogenesis, disorders related to treatment of vitiligo and modeling this skin disorder in laboratory. MethodStudies focusing on the pharmacotherapy of vitiligo disease and various medical treatments have been collected and summarized from 1992 until 2019. ResultsThis article provides reader with comprehensive and practical information about Vitiligo Disease, As the reader does not need to read several different sources to gather information about this disease. ConclusionWe mentioned new ideas and new methods to simulate the disease in laboratory in order to encourage scientists to pay more attention to this disease and do more clinical and laboratory research on finding new treatment of the disease.
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