Abstract
Vascular wilt caused by F. oxysporum (FOX) is one of the main limitations of producing several agricultural products worldwide, causing economic losses between 40% and 100%. Various methods have been developed to control this phytopathogen, such as the cultural, biological, and chemical controls, the latter being the most widely used in the agricultural sector. The treatment of this fungus through systemic fungicides, although practical, brings problems because the agrochemical agents used have shown mutagenic effects on the fungus, increasing the pathogen’s resistance. The design and the synthesis of novel synthetic antifungal agents used against FOX have been broadly studied in recent years. This review article presents a compendium of the synthetic methodologies during the last ten years as promissory, which can be used to afford novel and potential agrochemical agents. The revision is addressed from the structural core of the most active synthetic compounds against FOX. The synthetic methodologies implemented strategies based on cyclo condensation reactions, radical cyclization, electrocyclic closures, and carbon–carbon couplings by metal–organic catalysis. This revision contributes significantly to the organic chemistry, supplying novel alternatives for the use of more effective agrochemical agents against F. oxysporum.
Highlights
The genus Fusarium is considered one of the most adaptable and versatile in Eumycota.One of its most economically important species is F. oxysporum (FOX), an invasive phytopathogen responsible for vascular wilt and cortical rot in more than a hundred crops of commercial interest
FOX is responsible for a large percentage of economic losses in the agricultural sector worldwide
We present a compendium of organic compounds active against different species of FOX, their synthesis methods, and some recommendations and perspectives of the authors, formulated during the process of consolidation of the information to redirect the search for new molecules active against FOX systematically and rationally
Summary
The genus Fusarium is considered one of the most adaptable and versatile in Eumycota.One of its most economically important species is FOX, an invasive phytopathogen responsible for vascular wilt and cortical rot in more than a hundred crops of commercial interest. 2. Compendium of the Organic Molecules with the Highest Reported Antifungal Activity against FOX Species
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